Rhubarb alleviates hyperoxia induced lung injury in neonatal rats with bronchopulmonary dysplasia by inhibiting inflammation

Purpose: To investigate the effect of rhubarb on hyperoxia-induced lung injury in neonatal rats with bronchopulmonary dysplasia (BPD), and underlying mechanism.Methods: Sixty 4-day-old were assigned to air control, BPD, intervention groups, 20 each group. Immunoblotting was employed assay NF-κB expression. Levels malondialdehyde (MDA) SOD determined spectrophotometrically, while ELISA used measure serum levels IL-6, IL-8 TNF-α.Results: The peripheral blood TNF-α, IL-1β markedly higher BPD-exposed than control rats, reduced relative rats. activity lower tissue BPD MDA level elevated (p < 0.05). There marked up-regulation p65 expression but it hyperoxia model (p< 0.05).Conclusion: Rhubarb mitigated inflammation, oxidative stress rat by inhibiting reducing inflammatory factors.